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Drugs used in chemotherapy, such as cyclophosphamide and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, stopping them from dividing, or by stopping them from spreading.
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This patient developed an acute viral hepatitis-like syndrome 6 weeks after starting cyclophosphamide for an autoimmune condition.
The use of birth control is recommended while using cyclophosphamide.
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Neurological complications are dominated by IgM-related neuropathies (such as demyelinating peripheral neuropathy with IgM antibody activity against myelin-associated glycoprotein), but direct involvement of the central nervous system (CNS) by malignant lymphoid cells can occur.
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Cyclophosphamide directly attacks rapidly reproducing cells such as those in the immune system.
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When there is active disease, acutely ill patients are treated with prednisone, and long-term immunosuppression is with methotrexate and cyclophosphamide, although infliximab is emerging as a useful agent in some patients.
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You should seek advice from your doctor regarding additional side effects.
On a comparative basis, it is difficult to prove benefit when relapsing disease is followed with watchful waiting, or when the median survival is more than 10 years.
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It can also be used to treat and prevent cancer ().
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Therefore, it seems reasonable to offer patients with CIDP three cycles of IVIg every 3 weeks, and if there is no meaningful clinical response, consider an alternative first line treatment (corticosteroids or plasma exchange).
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Although lymph node biopsies are recommended whenever possible, sometimes immunophenotypic data are sufficient to allow diagnosis of lymphoma when fine-needle aspiration cytology is preferred.
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Symptoms such as lightheadedness, dizziness, nausea, headache, and allergic reactions have also been described in employees after the preparation and administration of antineoplastic drugs in unventilated areas.
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This includes participants who are, at the maintenance randomisation, randomised to receive no maintenance therapy, plus those who do not undergo maintenance randomisation either because of not being eligible or not being willing.
In one trial, fruit drinks administered just before chemotherapy were most effective in protecting against aversions to other foods.
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Predictors of Treatment Resistance and Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Study of 439 Cases in a Single Chinese Center.
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For example, bisphosphonate drugs such as zoledronic acid (Zometa) and pamidronate (Aredia, generic), and the biologic drug denosumab (Xgeva), are important supportive drugs for preventing fractures and reducing pain in people whose cancer has spread to the bones.
Treatment goals in ovarian cancer.
Immunosuppressant drugs include azathioprine, methotrexate, cyclosporine, tacrolimus, etanercept, and mycophenolate mofetil.
The poor response to pulse cyclophosphamide likely reflects late course disease when treatment was instituted, rather than an intrinsic failure of cyclophosphamide therapy.
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Chinese Medical Journal 128: 1555.
Association of Parkinson's disease with accelerated bone loss, fractures and mortality in older men: the Osteoporotic Fractures in Men (MrOS) study.
Capillaries are needed in all tissues for diffusion exchange of nutrients and metabolites.
Sorsa summarizes this information and discusses the factors, such as differences in urine collection timing and variations in the use of PPE, which could lead to disparate results.
The results of that long term storage stability testing are shown in Tables V-VIII.
The occurrence of lymphoproliferative disorders.
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Gemcitabine combined with cisplatin as first-line treatment in patients 60 years or older with epithelial ovarian cancer: a phase II study.
Is the drug known to be a human mutagen, carcinogen, teratogen or reproductive toxicant?
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For grade III or IV adverse events occurring on or after day 15 of a given cycle, they were held for the remainder of the cycle and reduced by one dose level beginning with the next cycle.
Macrophage Interactions and Granuloma Formation in Vasculitis.
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Severe and at times fatal CNS, GI and pulmonary toxicity (different from that seen with conventional therapy regimens of cytarabine) has been reported following some experimental dose schedules of cytarabine.
Risk was directly proportional to dose.
Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
It affects women twice as often as men.
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The presence of chronic health conditions can also impact aspects of psychological health.
How long should we maintain anti-HER2 therapy for metastatic breast cancer patients with complete remission?
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If the cancer is ductal carcinoma in situ (DCIS) or has not spread to the lymph nodes (node negative), the 5-year survival rates with treatment are up to 99%.
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The interval between exams is a function of the opportunity for exposure, duration of exposure, and possibly the age of the worker at the discretion of the occupational medicine physician, guided by the worker's history.
Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool.
Placebos also do not work as strongly in because the subjects do not know whether they might be getting a real treatment or a sham one.
Cyclophosphamide is indicated for the treatment of malignan.
Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors.
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The various NSAIDs and aspirin, if taken in full doses, usually have the same levels of anti-inflammatory effect.
The efficiency of protective gloves used in the handling of cytotoxic drugs.
In both phase I and phase II studies, single-agent clofarabine has been shown to be effective in inducing remission at well-tolerated doses in pediatric patients with multiple relapsed or refractory leukemia.
The Drug-Nutrient Interactions table may not include every possible interaction.
Circulating tumor cells and response to neoadjuvant paclitaxel and HER2-targeted therapy: A sub-study from the NeoALTTO phase III trial.
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Dose-reduced fludarabine, cyclophosphamide and rituximab is well tolerated in older patients with chronic lymphocytic leukemia and has preserved therapeutic efficacy.
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Before you receive cyclophosphamide, tell your doctor if you have an active or recent infection, a weak immune system, heart disease, liver or kidney disease, or if you have ever been treated with radiation.
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Once the patient has been in remission for at least a year, on maintenance therapy, prednisolone can be tapered off.
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Researchers have identified multiple gene alterations that contribute to a modestly increased risk for this disease.
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Compared with siblings, 5-year survivors had RRs approaching, if not exceeding, tenfold for heart failure, coronary artery disease, and cerebrovascular disease.
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Additionally, infections, drug toxicity, and environmental toxins can mimic ILD, creating significant diagnostic dilemmas for the clinician.
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